Selphyl PRFM – Pre & Post Treatment Instructions
The quality of your platelets will directly impact your results. If you have a history of chronic thrombocytopenia, other platelet disorders, recent serious illness (within 4 weeks), or are taking new medications, please discuss this with your provider before treatment. Certain conditions and medications can affect platelet quality and PRFM outcomes.
Pre-Treatment Instructions
- Avoid Alcohol: Do not consume alcohol for 72 hours prior to your treatment, as it can temporarily suppress platelet quality and function.
- Avoid Anti-Inflammatory Medications & Supplements for 7 days before treatment to reduce bruising risk:
- Prednisone
- Aleve (naproxen)
- Motrin, Ibuprofen
- Mobic
- Celebrex
- Fish oils & omega supplements
(If prescribed by your provider, do not stop these medications without their guidance.)
Post-Treatment Care
For the first 72 hours, the PRFM will form a clot under the skin where injected. This clot releases growth factors as it naturally dissolves, helping to stimulate collagen production and/or hair follicle activity. Keeping the area undisturbed is essential.
Care Guidelines:
- Wait 8–12 hours before washing or showering (unless otherwise instructed).
- Facial Injections: Lumps or swelling may be visible for 24–72 hours.
- Scalp Injections: Some dried blood or scabbing is normal.
- Microneedling with PRFM: Skin may feel tight and shiny.
- Avoid vibrating skincare tools (e.g., Clarisonic, facial massagers) for 7 days.
- Sun Protection is Critical:
- Avoid all sun exposure.
- Wear a mineral-only SPF 50+ and reapply every hour when outdoors, including while driving.
- No tanning beds.
- Avoid extreme cold or heat for 72 hours.
- Use cool or lukewarm water when bathing; avoid hot water for 8–12 hours.
- Do not rub or massage treated areas for 72 hours; use only a light touch if washing.
- No facials or anti-aging treatments to the face for 1 week.
- Avoid strenuous exercise for 24 hours.
- Try not to lie directly on treated areas for 72 hours.
- Small bumps or marks should fade within a few hours.
- Avoid makeup for the rest of the day on treated facial areas; you may apply makeup the next day with clean tools and a gentle touch.
- Some firmness at injection sites is normal for a few days and will soften over time.
Treatment Timeline & Results
- Results may take up to 30 days to begin appearing.
- Full results may take up to 3 months.
- Most patients complete a series of 3–4 monthly treatments for optimal improvement.
- Results typically last about 6 months; retreatment every 6 months is recommended to maintain results.
Additional Notes
- Keep treated areas clean. If wearing a mask, use a new, clean mask each time it is reapplied.
- PRFM is made from your own blood, so allergic reactions are not expected.
- Complications are rare and usually related to the injection process, not the PRFM itself.
- Contact our office immediately if you notice increased pain, drainage, redness, warmth at injection sites, or have any concerns.

