What to Expect When You Start Testosterone Injections: Timeline & Results

Starting testosterone injections is an important and often life-changing step for many people — whether for gender-affirming hormone therapy (GAHT), treating low testosterone (hypogonadism), or addressing other medical needs. Knowing what to expect, both physically and emotionally, helps prepare you for the journey ahead. In this blog, we break down the timeline of changes, common results, and what to keep in mind when you begin testosterone therapy.

Understanding Testosterone Injections

Testosterone injections deliver synthetic or bioidentical testosterone directly into the bloodstream. Common types include:

Testosterone cypionate

Testosterone enanthate

Testosterone undecanoate

Typically, injections are given weekly or biweekly into the muscle (intramuscular) or sometimes under the skin (subcutaneous). Your doctor will guide you on dosage, schedule, and monitoring.

Timeline of Physical and Emotional Changes

It’s important to understand that changes happen gradually — not overnight. Everyone’s body reacts at its own pace, but here’s a general timeline:

1–3 Months

Increased libido (sex drive)

Mood changes: Some people report feeling more confident, assertive, or emotionally steady, while others experience mood swings.

Increased oiliness of skin and possible acne, especially on the face and back.

Slight increase in muscle mass and strength.

Possible increase in appetite.

3–6 Months

Noticeable facial and body hair growth — especially on the chin, upper lip, chest, and abdomen.

Hairline changes or hair thinning at the temples or crown (depending on genetic predisposition).

Clitoral enlargement (in transmasculine individuals).

Fat redistribution — less stored in hips/thighs, more toward abdomen.

Continued muscle and strength gains.

6–12 Months

Voice deepening — often one of the most anticipated changes in transmasculine individuals.

Menstrual periods stop (if applicable), usually by month 6 but can vary.

Increased upper body strength and muscle definition.

Possible increase in red blood cell count — important to monitor with your doctor.

1–2 Years

Maximized hair growth patterns on face and body.

Continued changes in muscle and fat distribution.

Stabilization of voice.

Finalization of many physical changes, although some, like hair and muscle, continue to evolve over time.

Emotional and Psychological Impact

Hormone changes can also bring emotional shifts. Many trans individuals report feeling more aligned with their gender identity, experiencing relief and confidence. Others may encounter moments of anxiety, mood swings, or emotional ups and downs. Support systems matter — whether through friends, therapists, or community groups — to navigate these adjustments smoothly.

Monitoring and Health Checks

While testosterone offers many positive outcomes, it’s essential to stay under medical supervision. Your provider will:

Regularly check blood levels (testosterone, estrogen, hemoglobin, cholesterol).

Monitor blood pressure and cardiovascular health.

Discuss any side effects, such as acne, hair loss, or increased aggression.

Evaluate mental health and emotional well-being.

Self-injecting also requires proper technique to avoid infections or complications. Make sure you’re trained in safe injection practices.

Expected Results and Long-Term Outlook

The results from testosterone injections vary widely based on individual genetics, dosage, age, and health status. While some changes, like voice deepening and hair growth, are largely permanent, others — like fat distribution or muscle mass — depend on continued hormone use. Remember: Patience is key. Hormonal changes take months or years, and setting realistic expectations helps reduce frustration.

Partner With Pure Skin on Your Testosterone Journey

Starting testosterone injections is a meaningful and transformative step, but it’s not a one-size-fits-all process. By understanding the typical timeline of changes, staying in close communication with your healthcare provider, building a strong support network, and practicing patience and self-care, you set yourself up for the best possible experience. If you’re considering testosterone therapy or want expert guidance tailored to your goals, the team at Pure Skin is here to help. Contact us today to book and appointment and let us support you on your journey toward confidence, vitality, and well-being.

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